Hypothalamic dopamine signalling regulates brown fat thermogenesis
نویسندگان
چکیده
منابع مشابه
Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK
Estrogens play a major role in the modulation of energy balance through central and peripheral actions. Here, we demonstrate that central action of estradiol (E2) inhibits AMP-activated protein kinase (AMPK) through estrogen receptor alpha (ERα) selectively in the ventromedial nucleus of the hypothalamus (VMH), leading to activation of thermogenesis in brown adipose tissue (BAT) through the sym...
متن کاملBrown fat and thermogenesis.
Historical Background. ..................................................... 330 PhylogeneticDistribution .................................................. 332 AnatomyandTopology ................................................... 333 Vasculature of Brown Adipose Tissue. ...................................... 338 Microcirculation and vascularity .......................................... 338 G...
متن کاملHypothalamic control of brown adipose tissue thermogenesis
It has long been known, in large part from animal studies, that the control of brown adipose tissue (BAT) thermogenesis is insured by the central nervous system (CNS), which integrates several stimuli in order to control BAT activation through the sympathetic nervous system (SNS). SNS-mediated BAT activity is governed by diverse neurons found in brain structures involved in homeostatic regulati...
متن کاملHypothalamic Regulation of Brown Adipose Tissue Thermogenesis and Energy Homeostasis
Obesity and diabetes are increasing at an alarming rate worldwide, but the strategies for the prevention and treatment of these disorders remain inadequate. Brown adipose tissue (BAT) is important for cold protection by producing heat using lipids and glucose as metabolic fuels. This thermogenic action causes increased energy expenditure and significant lipid/glucose disposal. In addition, BAT ...
متن کاملLuxuskonsumption, diet-induced thermogenesis and brown fat: a critical review.
That a steady body weight can be maintained over long periods of life is a remarkable fact. Human food intakes vary widely I l l , and do not seem subjectively to be closely controlled; it is an old observation that they sometimes vary oppositely to what might be expected from body weight-it will be recalled that in Pharaoh’s dream [21 the lean kine were the over-eaters. How, then, is constancy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Metabolism
سال: 2019
ISSN: 2522-5812
DOI: 10.1038/s42255-019-0099-7